LillyDirect
Direct from Lilly
Eli Lilly's direct-to-consumer platform providing streamlined access to Zepbound (tirzepatide) at reduced cash-pay prices with home delivery.
Medications Available
Pros
- FDA-approved medication directly from manufacturer
- Significant discount vs retail pricing (up to 70% off)
- No purity or quality concerns (authentic Lilly product)
- Home delivery with cold chain handling
- Available through multiple telehealth partners
- Walmart retail pickup now available
- HSA/FSA eligible
- Prices reduced December 2025
Cons
- Requires separate prescription from provider
- Higher cost than compounded alternatives
- Only tirzepatide (Zepbound) available - no semaglutide
- Must refill within 45 days or pay standard higher prices
- With commercial insurance coverage, copay can be as low as $25/mo
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About LillyDirect
LillyDirect is Eli Lilly’s direct-to-consumer platform launched in 2024, providing streamlined access to Zepbound (tirzepatide) at significantly reduced cash-pay prices. The platform offers single-dose vials delivered directly to patients’ homes through Lilly-authorized distribution centers. Prices were reduced on December 1, 2025, with savings of $50-$100 per month compared to previous pricing.
How It Works
- Get a Prescription - Obtain a valid Zepbound prescription from your provider or telehealth partner
- Order Through LillyDirect - Access reduced self-pay pricing at lillydirect.com
- Home Delivery - Medication ships with cold chain handling, or pickup at Walmart
- Refill Regularly - Must refill within 45 days to maintain discounted pricing
Telehealth Partners
LillyDirect works with multiple telehealth providers for prescriptions:
- Teladoc Health
- LifeMD
- Form Health
- knownwell
- WeightWatchers Clinic
- Ro
- Hims & Hers
Pricing (Updated December 2025)
| Dose | Price | Previous Price |
|---|---|---|
| Zepbound 2.5mg Vial | $299/mo | $349/mo |
| Zepbound 5mg Vial | $399/mo | $499/mo |
| Zepbound 7.5mg Vial | $449/mo | $499/mo |
| Zepbound 10mg Vial | $449/mo | $499/mo |
| Zepbound 12.5mg Vial | $449/mo | $499/mo |
| Zepbound 15mg Vial | $449/mo | $499/mo |
Important: If you miss the 45-day refill window for doses 7.5mg and above, standard self-pay prices apply: 7.5mg: $599, 10mg: $699, 12.5mg: $849, 15mg: $1,049. You can re-enroll in the Self Pay Journey Program with your next order.
With Insurance: If you have commercial drug insurance with Zepbound coverage, you may pay as low as $25 for a 1- or 3-month supply.
Who Is This Best For?
- Patients who want authentic FDA-approved tirzepatide
- Those concerned about compounded medication quality
- People who already have a prescription from their provider
- Patients seeking significant savings vs retail Zepbound pricing ($1,000+/mo)
- Those who prefer to pay with HSA/FSA funds
The Bottom Line
LillyDirect offers the most affordable way to get authentic, FDA-approved Zepbound directly from the manufacturer. With prices reduced in December 2025, it’s now more competitive with compounded alternatives while providing peace of mind on quality and purity. The 45-day refill requirement is important to maintain pricing.
Last updated: February 2026
Last verified: February 2026
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